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如何利用组织 cDNA 芯片进行临床研究
1323 人阅读发布时间：2020-11-10 15:30
组织 cDNA 芯片是一个包含肿瘤和癌旁组织 cDNA 的阵列，可以直接用于实时荧光定量 PCR，检测目的基因（包括 mRNA、microRNA、circRNA 和 lncRNA）在不同样本中的表达。现有产品涵盖肺癌、食管癌、胃癌、结肠癌和肝癌。
优势：
更高的科研效率
1、无需收集样本
2、无需抽提、反转录
更完整的临床信息
1、样本具有详细的
2、临床随访信息
更可靠的实验结果
1、严格质控，高质量 RNA
2、看家基因 Actin 水平验证
更多水平验证
1、配套的石蜡样本组织芯片
2、帮助实现基因、蛋白水平双重验证
用组织 cDNA 芯片可以分析什么？
1、不同基因在癌组织和癌旁组织中的表达差异，例如下图：
2、结合临床参数，分析临床相关性
3、进行生存分析
组织 cDNA 产品列表
组织 cDNA 芯片参考文献
1. Lehtinen L, Vainio P, Wikman H, Huhtala H, Mueller V, Kallioniemi A, Pantel K, Kronqvist P, Kallioniemi O, Carpen O et al: PLA2 G7 associates with hormone receptor negativity in clinical breast cancer samples and regulates epithelial-mesenchymal transition in cultured breast cancer cells. The journal of pathology Clinical research 2017, 3(2):123-138.
2. Lin KT, Yeh YM, Chuang CM, Yang SY, Chang JW, Sun SP, Wang YS, Chao KC, Wang LH: Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B. Nature communications 2015, 6:5917.
3. Viphakone N, Cumberbatch MG, Livingstone MJ, Heath PR, Dickman MJ, Catto JW, Wilson SA: Luzp4 defines a new mRNA export pathway in cancer cells. Nucleic acids research 2015, 43(4):2353-2366.
4. Kim Y, Kim J, Jang SW, Ko J: The role of sLZIP in cyclin D3-mediated negative regulation of androgen receptor transactivation and its involvement in prostate cancer. Oncogene 2015, 34(2):226-236.
5. Hollander L, Guo X, Velazquez H, Chang J, Safirstein R, Kluger H, Cha C, Desir GV: Renalase Expression by Melanoma and Tumor-Associated Macrophages Promotes Tumor Growth through a STAT3-Mediated Mechanism. Cancer research 2016, 76(13):3884-3894.
6. Young HL, Rowling EJ, Bugatti M, Giurisato E, Luheshi N, Arozarena I, Acosta JC, Kamarashev J, Frederick DT, Cooper ZA et al: An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition. The Journal of experimental medicine 2017, 214(6):1691-1710.
7. Blake A, Dragan M, Tirona RG, Hardy DB, Brackstone M, Tuck AB, Babwah AV, Bhattacharya M: G protein-coupled KISS1 receptor is overexpressed in triple negative breast cancer and promotes drug resistance. Scientific reports 2017, 7:46525.
8. Tseng HY, Chen YA, Jen J, Shen PC, Chen LM, Lin TD, Wang YC, Hsu HL: Oncogenic MCT-1 activation promotes YY1-EGFR-MnSOD signaling and tumor progression. Oncogenesis 2017, 6(4):e313.
优势：
更高的科研效率
1、无需收集样本
2、无需抽提、反转录
更完整的临床信息
1、样本具有详细的
2、临床随访信息
更可靠的实验结果
1、严格质控，高质量 RNA
2、看家基因 Actin 水平验证
更多水平验证
1、配套的石蜡样本组织芯片
2、帮助实现基因、蛋白水平双重验证
用组织 cDNA 芯片可以分析什么？
1、不同基因在癌组织和癌旁组织中的表达差异，例如下图：
2、结合临床参数，分析临床相关性
3、进行生存分析
组织 cDNA 产品列表
组织 cDNA 芯片参考文献
1. Lehtinen L, Vainio P, Wikman H, Huhtala H, Mueller V, Kallioniemi A, Pantel K, Kronqvist P, Kallioniemi O, Carpen O et al: PLA2 G7 associates with hormone receptor negativity in clinical breast cancer samples and regulates epithelial-mesenchymal transition in cultured breast cancer cells. The journal of pathology Clinical research 2017, 3(2):123-138.
2. Lin KT, Yeh YM, Chuang CM, Yang SY, Chang JW, Sun SP, Wang YS, Chao KC, Wang LH: Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B. Nature communications 2015, 6:5917.
3. Viphakone N, Cumberbatch MG, Livingstone MJ, Heath PR, Dickman MJ, Catto JW, Wilson SA: Luzp4 defines a new mRNA export pathway in cancer cells. Nucleic acids research 2015, 43(4):2353-2366.
4. Kim Y, Kim J, Jang SW, Ko J: The role of sLZIP in cyclin D3-mediated negative regulation of androgen receptor transactivation and its involvement in prostate cancer. Oncogene 2015, 34(2):226-236.
5. Hollander L, Guo X, Velazquez H, Chang J, Safirstein R, Kluger H, Cha C, Desir GV: Renalase Expression by Melanoma and Tumor-Associated Macrophages Promotes Tumor Growth through a STAT3-Mediated Mechanism. Cancer research 2016, 76(13):3884-3894.
6. Young HL, Rowling EJ, Bugatti M, Giurisato E, Luheshi N, Arozarena I, Acosta JC, Kamarashev J, Frederick DT, Cooper ZA et al: An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition. The Journal of experimental medicine 2017, 214(6):1691-1710.
7. Blake A, Dragan M, Tirona RG, Hardy DB, Brackstone M, Tuck AB, Babwah AV, Bhattacharya M: G protein-coupled KISS1 receptor is overexpressed in triple negative breast cancer and promotes drug resistance. Scientific reports 2017, 7:46525.
8. Tseng HY, Chen YA, Jen J, Shen PC, Chen LM, Lin TD, Wang YC, Hsu HL: Oncogenic MCT-1 activation promotes YY1-EGFR-MnSOD signaling and tumor progression. Oncogenesis 2017, 6(4):e313.